Murighiol, a traditional fishing village, is home to the ruined Roman city of Halmyris, one of the most important ancient sites in Romania. The city was continuously inhabited from the 6th century BC to the 7th century AD. Although a basilica and a crypt containing the tomb of Epictet and Astion, the earliest Romanian Christian martyrs, have been discovered here, much of the ruins remain unexcavated. A visit offers the chance to see an ancient city still in the process of being uncovered.

Murighiol is the jump-off point for boats to Uzlina. Located 24 miles east of Tulcea, Uzlina is home to the offices of the Danube Delta Biosphere Reserve and the Jacques Cousteau Foundation. The Wild Danube floating hotel in Uzlina provides facilities for hiring boats and guides to venture into some of the more interesting parts of the Delta.